Bardoxolone methyl CAS NO.218600-53-4

CAS NO.	218600-53-4
Product Name	NSC713200
Synonyms	RTA402;NSC 713200;RTA 402;CDDO Methyl ester;Bardoxolone methyl
Formula	C32H43NO4
Molecular Weight	505.69
Spec / Purity	98%
Supply Capacity	can supply g scale
Product Description	Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.
Details	Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon- in mouse macrophages with IC50 of 0.1 nM. [1] Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis.Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke.

CAS NO.	218600-53-4
Product Name	NSC713200
Synonyms	RTA402;NSC 713200;RTA 402;CDDO Methyl ester;Bardoxolone methyl
Formula	C32H43NO4
Molecular Weight	505.69
Spec / Purity	98%
Supply Capacity	can supply g scale
Product Description	Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.
Details	Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon- in mouse macrophages with IC50 of 0.1 nM. [1] Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis.Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke.